Duke of Segorbe is an hereditary title in the peerage of Spain, accompanied by the dignity of Grandee and granted in 1469 by John II of Aragon to his nephew, Enrique de Aragón, son of Infante Henry, Duke of Villena by his second wife, Beatriz de Pimentel (1416-1490), from whom the Ducal line of the House of Medinaceli descends.