The protein encoded by this gene belongs to the
dystrobrevin subfamily and the
dystrophin family. This protein is a component of the
dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including
dystroglycans,
sarcoglycans,
syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of
muscular dystrophy. This protein may be involved in the formation and stability of
synapses as well as the clustering of
nicotinic acetylcholine receptors. Multiple
alternatively spliced transcript variants encoding different isoforms have been identified. == Clinical significance ==