The East Hamilton Avenue Historic District encompasses a 20th-century residential area of Wynne, Arkansas, reflecting its growth between approximately 1920 and 1940. It extends along East Hamilton Avenue, between North Falls Boulevard and Killough Road, and includes properties on Eldridge Court. East Hamilton Avenue represents the best-preserved area of development from this period and was developed gradually beginning in the late 19th century, growing from west to east. The oldest house in the district, the Giboney-Robertson-Stewart House, is a Queen Anne Victorian built circa 1895. Most of the houses were built after 1920 and are predominantly Craftsman, Colonial Revival, and Tudor Revival in character. There are a few Spanish (Mediterranean) Revival houses and a few early ranch houses, which were generally built between 1940 and 1950.