Reid was born in
Fincastle, Virginia, and studied chemistry at
Johns Hopkins University. He received a doctorate for work on kinetics of the hydrolysis of acid amides under
Ira Remsen in 1898. He became a teacher of chemistry in 1908 and worked until 1936. During World War I he was involved in research on chemical warfare agents at the American University Experimental Station. He was involved in creating tear gas. He specialized in organic sulfur compounds. He identified the mechanism of ester hydrolysis in 1910, based on his studies on thioesters and thiols, noting that it involves the fission of acyl-oxygen. He wrote an autobiography at the age of 100 that he called "My First One Hundred Years". He travelled to research departments by bus four times a year encouraging and advising researchers. Even after his retirement, with failing eyesight and arthritis, he published 140 articles. He learned Braille, typing by touch and had students read material for him. He served as an industrial and government consultant at least until 1950. In 1961 he produced a second edition of his 1924 book
Invitation to Chemical Research adding a Spanish translation as well. He and his wife Margaret had a daughter and two sons. His wife predeceased him in 1967. Johns Hopkins University established the E. Emmet Reid Chair in chemistry in his honor. == Selected publications ==