Gamble's early work was alongside
Ray Peacock, with whom he presented two different series of
The Peacock and Gamble Podcast, totalling over 100 episodes. He also appeared on television, performing a 15-minute set on the extended version of ''
Russell Howard's Good News on BBC Three in late 2010. He performed with Peacock at the Edinburgh Festival Fringe in 2011, 2012 and 2013, as well as supporting Greg Davies on his successful Firing Cheeseballs at a Dog'' Tour in 2011. Gamble also recorded a series of radio shows with Peacock on
FUBAR Radio. In 2014, Gamble debuted solo at Edinburgh Fringe with the show
Gambletron 5000, returning in 2015 with
Lawman and in 2016 with
Stampede. His stand-up performances contain much observational comedy, often aimed at himself, including discussion of his
Type 1 diabetes, which he was diagnosed with at 13; he chose that as the central topic of his 2018 Edinburgh Fringe show
Blizzard and his
Amazon Prime Video special
Blood Sugar. Gamble was a regular panellist on the BBC panel show
Mock the Week from July 2015. In the same year, he appeared with
Amy Hoggart in
Almost Royal, a faux-reality show on
BBC America, in which the two portrayed aristocratic siblings Georgie and Poppy Carlton. The first series aired on
E4 in the UK and was followed by a second series in 2016. He guest-hosted the
Elis James and John Robins Show on
Radio X in 2017 and 2018. Since 2018, Gamble has presented the podcast
Off Menu with Ed Gamble and James Acaster with fellow comedian
James Acaster as well as a weekly
Radio X show with
Matthew Crosby since 2019. Gamble won the ninth series of
Taskmaster in 2019. In 2022, Gamble featured in the second "Champions of Champions" special with fellow winners from series six to ten:
Liza Tarbuck,
Kerry Godliman,
Lou Sanders and
Richard Herring. He finished in last place. In October 2020, Gamble began presenting
Taskmaster The Podcast, the official
podcast companion to the TV show, following the series' move to
Channel 4 from
Dave. In 2023, Gamble hosted a non-broadcast pilot of
Foodmaster, a food-themed spin-off of
Taskmaster. In May 2022, Gamble was announced as one of six rotating co-hosts joining
Alexander Armstrong on
Pointless to replace
Richard Osman, alongside
Sally Lindsay,
Konnie Huq,
Lauren Laverne,
Alex Brooker and
Stephen Mangan. Gamble appeared with Acaster on the fifth series of
Celebrity Hunted (2023), which tasked participants with evading "Hunters" around the UK for a fortnight. During their appearance they ate in a
Michelin starred restaurant, called into Gamble's
Radio X programme, and released a video mocking the Hunters. Acaster also gave Gamble a tattoo. Gamble escaped after Acaster goaded the Hunters to the
Taskmaster house and squirted them with a water gun. Gamble met with his wife and hid in a brewery and a climbing centre, but was caught soon after. In 2022, Gamble toured the UK with his stand-up show
Electric. In 2024, a poster advertising Gamble's
Hot Diggity Dog tour fell foul of
Transport for London's ban on
junk food advertising; to comply with the rules, an image of a
hot dog was replaced with a
cucumber. In October 2023, Gamble published his debut book, titled
Glutton: The Multi-Course Life Of A Very Greedy Boy, an autobiography focused through his lifelong obsession with food. In January 2024, he hosted
The Traitors: Uncloaked, which was a visual podcast that accompanied
the second series of The Traitors. It returned with Gamble as host for the
third series in January 2025 and the
fourth series in January 2026. Gamble also hosted
The Celebrity Traitors: Uncloaked for
the celebrity version of the show. His most recent tour,
Hot Diggity Dog, included an Autumn tour extension with 85 UK dates and an
Australia and
New Zealand leg of the tour starting on 15April 2024. ==Personal life==