Eddie made his professional boxing debut in 2000 at the age of 18, defeating Tyrone Austin by second-round TKO. In the span of five years, Chambers won 22 fights in a row before facing his first notable opponent,
Ross Puritty, who had faced another prospect
Alexander Dimitrenko six months prior in a losing effort. Chambers won the fight by unanimous decision (UD), with scores 99–91, 98–92 and 99–91. He then defeated local rival Robert Hawkins, winning the Pennsylvania heavyweight title. Chambers won the fight by fourth-round TKO. Chambers dominated Rossy throughout the fight, ultimately giving him his first career loss after the referee stopped the fight in round 7, preventing battered and bruised Rossy from continuing absorbing punishment. Rossy eventually suffered his second loss at the hands of
Alexander Dimitrenko by fifth-round TKO. was 3–2–1 in his last six fights, losing to
James Toney and
Tony Thompson by unanimous decisions but defeating then-highly regarded prospest,
Olympic Gold medalist Audley Harrison. Guinn was also known for his durability, having never been stopped in his entire career. Chambers defeated Guinn by a lopsided unanimous decision. claimed to be in the best shape of his career. Brock weighed in at 241 lbs, the heaviest in his entire career and almost 17 lbs heavier than in his bout against Klitschko. The fight took place at
Emerald Queen Casino in
Tacoma, Washington and was aired live on
Showtime. Chambers damaged Brock's right eye during the bout, which, after subsequent botched surgery, prompted Brock to retire from the sport. In the final, which took place less than three months later, Chambers faced undefeated
Alexander Povetkin, who had beaten former IBF world champion
Chris Byrd in semifinals by eleventh-round TKO. The bout took place in
Berlin,
Germany. Chambers was doing the better work in early rounds, landing cleaner, harder shots, but was eventually overwhelmed by Povetkin's relentless pressure. Ultimately the bout went the distance, with Povetkin being declared the winner by unanimous decision. The scores were 117–111, 116–112 and 119–109. Prior to facing Chambers, however, Peter had lost the world championship to
Vitali Klitschko, and was looking to bounce back to the heavyweight title picture. The fight took place at
Nokia Theatre in
Los Angeles, and was aired on
ESPN2. Chambers injured his right thumb early in the third round, but was able to outbox Peter for the majority of the fight, frustrating his opponent with speed and quickness and blocking most of Peter's shots using his gloves and arms. As a result, Chambers was declared the winner by majority decision, with judges scoring the bout 99–91, 96–94 and 95–95. Some observers criticized the 95–95 score, believing Peter had not done enough to win more than three rounds. At the time of the fight, Chambers was ranked No.6 heavyweight contender by
The Ring, while Dimitrenko was ranked No.8 by the same publication. Dimitrenko was also ranked within top 5 by all major sanctioning bodies. Chambers weighed in at 208 1/4 lbs, the lightest since 2003. Chambers was outweighed by Dimitrenko by 45 1/2 lbs. Unlike his previous fights, Chambers was the aggressor, taking the centre of the ring and constantly pressing Dimitrenko against the ropes. After putting pressure and slowing down Dimitrenko's left arm in the early rounds, Chambers established his rhythm by the fifth, successfully finding his way inside Dimitrenko's jab. Dimitrenko received a standing count in the seventh round after a left hook to the body, and was knocked down in the tenth after another left hook, this time to the chin. Chambers won the fight by majority decision. The judges scored the bout 117–109, 116–111 and 113–113, with some experts criticizing the 113–113 score. Coming into the bout, Chambers was ranked No.3 heavyweight contender by
The Ring, whereas Wladimir was the magazine's champion. The fight generated little interest in the
United States, where it was not televised by any TV station but was aired on the Klitschko's official website instead. The bout turned-out to be one-sided, with the champion winning rounds keeping Chambers at the end of his jab and occasionally throwing straight right hands. In between the championship rounds, Klitschko was criticized by his trainer
Emmanuel Steward for not fighting aggressively, despite comfortably winning on the scorecards.
Post-Klitschko fights; injuries and inactivity Chambers returned to the ring almost eleven months later, defeating
Derric Rossy again, this time by unanimous decision, in an
IBF title eliminator. He was scheduled to face
Tony Thompson on 28 October 2011 in a bout televised by
Showtime, but had to pull out due to spinal injury. He was then due to face former
WBO world heavyweight champion
Siarhei Liakhovich on 21 January 2012 at
Asylum Arena in Philadelphia, in the inaugural main event of the Fight Night card televised by
NBC Sports, but was forced to withdraw after fracturing his ribs during training camp. Chambers returned to the ring sixteen months later, against former
WBC light-heavyweight and
IBF and
The Ring cruiserweight champion
Tomasz Adamek for the vacant
IBF North American heavyweight title. Both Adamek and Chambers were praised for taking the fight with no world title nor mandatory position on the line, with Adamek trying to re-establish himself after the tenth-round TKO loss to
Vitali Klitschko. Coming into the fight, Adamek was ranked No.3 heavyweight contender by
The Ring, while Chambers, who had had only one fight in the last two years and three months, was unranked by the publication. and often switched between orthodox and southpaw stances throughout the rest of the fight, throwing shots almost exclusively with the right hand, mostly connecting with overhand punches. Adamek was more active since round 3, frequently switching up from counterpuncher to aggressor. The bout lasted full twelve rounds, with Adamek being declared the winner by unanimous decision with scores 116–112 (twice) and 119–109. Most observers thought that the bout was close, with many of them criticizing the 119–109 score. In early 2012, then undefeated prospect
Deontay Wilder called out Chambers for a step-up fight along with
David Price. By late 2012,
Tyson Fury was in talks with promoter
Kathy Duva to fight Chambers in a similar step-up fight, however talks stalled due to the injury sustained in the Adamek fight. Chambers made his return to the ring fourteen months later, moving down to
cruiserweight to fight
South African contender
Thabiso Mchunu. Having had fought only twice in three and a half years prior to the bout, Chambers gave a relatively poor showing and lost the fight by unanimous decision. After failing to secure any major world title shots despite being ranked in the top five in the world by multiple sanctioning organizations, Chambers then signed with manager
Al Haymon and made his U.S. return in late 2015, defeating journeyman Galen Brown by third-round TKO. He then faced
Gerald Washington on
Premier Boxing Champions on
Fox, losing the bout by a lopsided unanimous decision. Following the loss, Chambers subsequently retired from the sport.
Comeback On November 17, 2017, World Heavyweight Champion
Anthony Joshua called out and sent Chambers a threatening racist-filled message calling him a "Disgrace to the superior black race", in hopes to lure Chambers back into the ring after years of back-and-forth messages exchanged through the UK boxing media. Former sparring partner and team member
Tyson Fury came on record defending Chambers saying that Joshua finally showed his true colors. On February 7, 2023, at age 40, Chambers made his return to the ring after a near 7 year lay-off with a 3rd-round TKO victory against Corey Williams. Chambers weighed in as a heavyweight at 226 ¾ lbs. Per trainers James Ali Bashir and Steve Upsher, Chambers will look to compete at heavyweight but keep close attention to a newer WBC weight class of
bridgerweight, which falls between 200 and 224-pounds. ==Other media==