Salcedo is a product of the
Genoa youth academy. On 20 August 2017, at the age of 15, he made his debut with the senior team in
Serie A in a 0–0 away draw against
Sassuolo, coming on as an 81st-minute substitute for
Andrey Galabinov. On 16 July 2018, Salcedo joined
Inter Milan on a season-long loan deal with an option to make the deal permanent. He played with Inter's U19 team in the
Campionato Primavera 1 and the
UEFA Youth League. The deal was made permanent on 19 June 2019 for €8 million. In summer 2019 he joined the newly promoted
Hellas Verona on loan. On 3 November 2019, he scored his first Serie A goal, in the home match won 2–1 against
Brescia. On 25 September 2020 he re-joined Verona on another season-long loan. On 31 August 2021 he joined
Spezia on a season-long loan. On 1 September 2022, Salcedo moved to
Bari on loan with an option to buy. On 31 January 2023, Bari mutually terminated Salcedo's loan deal with Inter Milan, and later on the same day he was loaned out to fellow Serie B club
Genoa until the end of season, with an option to buy. On 25 August 2023, Salcedo joined Spanish
Segunda División club
Eldense on loan with an option to buy. On 10 January 2024, Salcedo moved on a new loan to
Serie B club
Lecco, with an option to buy. On 11 September 2024, Salcedo joined
Greek Super League club
OFI on a year-long loan. On 2 July 2025, Salcedo joined OFI on a permanent basis. On 14 January 2026, OFI eliminated AEK in the quarter final of the Greek Cup with a 0-1 score. The only goal of the match was scored by Eddie Salcedo in the 80th minute of the game. ==International career==