He began making music using his stage name,
Eddy Kenzo, in 2008. That year, he released his first song, "Yannimba", with Mikie Wine. In 2010, he released another single, "Stamina". The song was used as a theme song by politicians during the
2011 Ugandan general election. At the
Pearl of Africa Music Awards in 2011, Kenzo received the Best New Artist award. Kenzo also established his Big Talent Entertainment record label in 2011. He continues to serve as a member of that venture. Kenzo continued releasing music in 2012. In 2013, he held his first concert at the
Kyadondo Rugby Club that year in support of the track, "Kamunguluze". Kenzo's first major international breakthrough came with 2014's "Sitya Loss" and the accompanying album of the same name. A YouTube video featuring a group of Ugandan children known as the
Ghetto Kids dancing to the song went viral after it was shared on social media by record executive
Sean Combs in September 2014. As of March 2022, the video has accumulated nearly 42 million views on YouTube. Kenzo also started a petition to earn the children an appearance on
The Ellen DeGeneres Show. After the release of "Sitya Loss" and the album of the same name, Kenzo went on a brief United States tour with
dancehall musician,
DeMarco. In January 2015, Kenzo performed at the opening ceremonies of
that year's Africa Cup of Nations in
Equatorial Guinea alongside
Akon. He also performed at the
tournament final. Around that time, he produced a remix to his 2014 single, "Jambole", with a guest appearance from Nigerian singer,
Kcee. In June 2015, Kenzo was honored with the BET Award for Viewer's Choice Best New International Artist. He was the first East African artist to win a BET Award. In July 2015, he performed at the KigaliUp Music Festival in
Rwanda's
capital. In October of that year, he released a remixed version of his song, "Mbilo Mbilo", featuring Nigerian singer,
Niniola. The original version of that song later appeared on the soundtrack for the 2016 film
Queen of Katwe. In December 2015, Kenzo released the lead single, "Soraye", from his second album,
Zero to Hero. In March 2016, he went on a tour Africa, with stops in
Kenya,
Ivory Coast,
Mali, and others. Later that month, he released
Zero to Hero. Throughout the remainder of 2016, Kenzo earned a writing credit on
Jidenna's "Little Bit More", was featured on the
Mi Casa single "Movie Star", and won an All Africa Music Award for his "Mbilo Mbilo" remix. He also went on another US tour late in the year. In May 2017, Kenzo was named the ambassador of the Kenyan Tourism Board and was appointed to a similar role in Uganda the following year. In July 2017, Kenzo went on a European tour ahead of the release of his third studio album,
Biology, a month later. The album featured guest appearances from artists like
Mani Martin,
Werrason, and Mi Casa, among others. It also featured the single "Jubilation", which had an accompanying music video that won the Best East African Music Video Award at the
Zanzibar International Film Festival. He won awards at that year's All Africa Music Awards, including Best East African Male Artist. He later donated the award, along with his 2015 BET Award, to the
Uganda Museum in Kampala. In July 2018, he performed alongside Triplets Ghetto Kids at multiple African music festivals in Canada, including Afrofest in
Toronto. He also performed at the One Africa Music Festival in
Dubai later in the year. In October 2018, he released his fourth studio album,
Roots, which featured the single "Body Language". Kenzo also announced a 10-year anniversary concert in celebration of his time as a musical artist. The concert took place on 4 January 2019 in the Victoria ballroom of the
Serena Hotel in Kampala. Leading up to the concert, Kenzo released a new music video each week for a song from
Roots for two months. In March 2019, it was announced that Kenzo would be featured alongside Triplets Ghetto Kids in an upcoming music video for American singer
Chris Brown's "Back to Love". In April 2019, Kenzo released the single, "Signal" with an accompanying music video. from
Tanzania for the hit love song "SoulMate". In 2022, Kenzo collaborated with US musician
Matt B on "Gimme Love". The song entered the
Billboard US Afrobeats Songs at number 49 in October and peaked at number 36 in November that year. He and Matt B were nominated for the
Grammy Award for Best Global Music Performance at the
65th Annual Grammy Awards for the song. The nomination made Kenzo the first Ugandan musician working and living in Uganda to receive a Grammy nomination. On 22 August 2024, Kenzo was appointed as the senior presidential adviser on Creatives by President
Yoweri Museveni. This role involves advising on matters related to the creative industry, which includes music, performing arts, and other creative sectors. Kenzo’s appointment is seen as a significant step towards bolstering the creative industry in Uganda, which has been seeking more governmental support and recognition. His appointment followed a meeting with President Museveni and other musicians at State House Entebbe. He became one of more than 160 presidential advisers. In 2025, Kenzo received a nomination for the
Grammy Award for Best African Music Performance for "Hope & Love" with
Mehran Matin. == Philanthropy ==