The human corneal transplantation (
keratoplasty) had been attempted with little or no success throughout the 1800s using both animal donor cornea and human graft tissue. The donor tissue, whether animal or human, could either be transplanted as a full-thickness disc of cornea or partial-thickness (layers or lamellae) cornea attached to the host eye. By the late 1880s, lamellar grafts were considered to have a better chance of success than full-thickness corneal grafting which invariably failed a few days after the operation. whose corneas in both eyes had turned white-gray and opaque a year earlier while working with
slaking lime. Around the same time he examined Glogar, an 11-year-old boy named Karl Brauer was brought to Zirm's clinic with penetrating eye-injury to both eyes and iron metal foreign bodies irretrievably lodged in his eyes. When attempts to save Brauer's eyes were unsuccessful, Zirm, with the boy's father's permission Zirm 's method remains the basis for repairing corneal damage. ==Interests outside ophthalmology==