He was deputy-governor of the
Merchant Adventurers' Company at
Delft from 1623 until 1633. On his departure from England (October 1623) the
East India Company invited him to act as one of their commissioners at
Amsterdam to negotiate a private treaty with the Dutch; he had probably been employed by the Merchant Adventurers' Company in 1616 in a similar capacity. His fellow-commissioner was Robert Barlow, East India merchant. The negotiations, however, were fruitless, and the report of the
Amboyna massacre made progress difficult. In low health, Misselden returned to England, and presented to the company an account of the negotiations (3 November 1624). He returned to Delft at the end of November 1624, and during the next four years he was again employed by the East India Company in the Amboyna matter. He was also entrusted with the negotiations on behalf of the Merchant Adventurers' Company for a reduction of the duties on English cloth.
Dudley Carleton, the English ambassador at
the Hague, believed that he had been bribed by the Dutch, while the
States-General, on the other hand, suspected him of compromising their interests by sending secret information to England, and confronted him (October 1628) with some of his letters. Missenden was aggrieved at his treatment, and declined to have anything further to do with the East India Company's affairs. His case was taken up by the privy council, and reparation was made (1628). Misselden supported
William Laud's schemes for bringing the practice of the English congregations abroad into conformity with that of the
Church of England. The merchant adventurers at Delft were strongly
presbyterian, and
John Forbes, their preacher, exercised great influence. Misselden's attempts to impose the
Book of Common Prayer were met by plots to eject him from his position, and he and Forbes were bitterly opposed. He was ultimately turned out, and the company chose in his place Samuel Avery, a presbyterian. Two years later (1635) abortive attempts were made to obtain his election as deputy-governor at
Rotterdam, and
Charles I addressed a letter to the Merchant Adventurers' Company vainly recommending them to deprive Robert Edwards who was in the post. Behind this lay the fact that Missenden had furnished
Philip Burlamachi with large sums for the king's service, and in May 1633, £13,000 remained unpaid. Misselden was subsequently employed by the Merchant Adventurers' Company on missions. Around 1650 he was in
Hamburg, and tried to make himself useful to the Parliamentary regime; but his reputation as a royalist told against him. ==Writings==