Immediately after graduating from medical school, he became a
ship's doctor in the
U.S. Navy. He served during the
Mexican–American War as an assistant surgeon. This profession, did not sit well with his Quaker family as well as his local Meeting, which disowned him for violating his pledge of pacifism. As a Navy
physician, Squibb became disenchanted with the poor quality of medicines used on American military vessels and, as a result, in 1854 he invented an improved method of distilling
ether, an
anesthetic. He gave away his
distillation method, rather than
patent it for profit.
Squibb Company In 1858, he left the military and started his own pharmaceutics manufacturing business in
Brooklyn. His
laboratory burned down three times, and in one of these instances an ether explosion left Squibb badly burned. Despite his severe injury, Squibb reopened his laboratory a year later and by 1883, he was manufacturing over 300 products being sold globally. In 1892, Squibb created a partnership with his two sons, Dr. Edward H. Squibb and Charles F. Squibb, a firm known for generations afterwards as E. R. Squibb and Sons. Squibb was known as a vigorous advocate of quality control and high purity standards within the fledgling pharmaceutical industry of his time, at one point self-publishing an alternative to the
U.S. Pharmacopeia (''Squibb's Ephemeris of Materia Medica
) after failing to convince the American Medical Association to incorporate higher purity standards. Mentions of the Materia Medica'', Squibb products, and Edward Squibb's opinion on the utility and best method of preparation for various medicines are found in many medical papers of the late 1800s. Squibb Corporation served as a major supplier of medical goods to the
Union Army during the
American Civil War, providing portable medical kits containing
morphine, surgical anesthetics, and
quinine for the treatment of
malaria (which was endemic to the eastern United States at that time). Squibb was elected to the
American Philosophical Society in 1897. ==Personal life==