Edward married Honora Rogers, a daughter of Sir Richard Rogers (c. 1527 – 1605) of
Bryanston, Dorset, a
knight of the shire for
Dorset in 1572, by his wife Cecilia Luttrell, daughter of Sir Andrew Luttrell (1484–1538),
feudal baron of Dunster of
Dunster Castle in Somerset. Honora was the sister of Andrew Rogers (died c. 1599), MP, of Bryanston, who earlier had married (as his second wife) Lord Beauchamp's aunt Lady Mary Seymour (born 1552). Beauchamp's father the earl was strongly opposed to the marriage and sent a certain George Ludlow to discuss the position with the Rogers family. Ludlow reported back that Honora was "a baggage" and her father Sir Richard Rogers "a fool" and that Lord Beauchamp had originally intended to have "but a night's lodging with her". The earl believed that Sir Richard had encouraged the marriage and that "though outwardly he did nothing" to oppose or promote the marriage, nevertheless his daughter had "inwardly his goodwill". By his wife Honora he had three sons and three daughters: • Edward Seymour, Lord Beauchamp (1586–1618), who married Lady Anne Sackville, daughter of
Robert Sackville, 2nd Earl of Dorset. He predeceased his grandfather the 1st Earl of Hertford and died without issue. •
William Seymour, 2nd Duke of Somerset (1588–1660) and 2nd
Earl of Hertford, who in 1660 eventually regained the dukedom which had been granted to his great-grandfather
Edward Seymour, 1st Duke of Somerset (c. 1500 – 1552) •
Francis Seymour, 1st Baron Seymour of Trowbridge (c. 1590 – 1664), of
Marlborough Castle, the grandfather of
Francis Seymour, 5th Duke of Somerset (1658–1678) and of his younger brother
Charles Seymour, 6th Duke of Somerset (1662–1748), "The Proud Duke" •
Honora Seymour (bef. 1594 – 1620), wife of
Sir Ferdinando Sutton, son of
Edward Sutton, 5th Baron Dudley • Anne Seymour • Mary Seymour ==Death and succession==