E-cigarette liquid, E-Cig liquid, vaping juice, e-juice, e-fluid is the mixture used in vapor products including e-cigarettes. Propylene glycol and glycerin typically comprise 95% , with the remaining 5% combining flavorings, nicotine, and other additives. Flavorings may contain
menthol, sugars, esters, and
pyrazines. Caffeinated e-liquids typically contain considerably less caffeine than dietary products. E-liquids are available with vitamins or cannabis flavors. More than 90% of e-liquids contain nicotine. Some are unflavored. E-liquids may contain
THC or other
cannabinoids. Some e-liquids contain a little alcohol. Nicotine levels vary. A user survey reported that 97% of respondents used nicotine e-liquids. A 2016 study reported that measurable amounts of arsenic, nickel and other metals were present in some e-liquids. Over 80 chemicals, including
formaldehyde and metallic nanoparticles were reported in e-liquids (2019). E-liquid can contain toxicants and impurities. A 2013 study reported as high as five times the permitted levels of impurities. TSNAs present in tobacco smoke were reported in trace amounts. A 2013 review of other e-liquids did not detect diethylene glycol. The majority of the e-liquids analyzed contained NNN from 0.34 to 60.08 μg/L and NNK from 0.22 to 9.84 μg/L. E-liquids often contain unknown and/or undisclosed substances. Poor quality control may allow nicotine and TSNAs to be present in e-liquids labelled 'no nicotine'. A 2015 study reported hydrocarbons, terpenic compounds and aldehydes, particularly formaldehyde and
acrolein in some e-liquids. A 2014 study reported that e-liquids from a specific manufacturer contained greater amounts of ethylene glycol than glycerin or propylene glycol, possibly the result of improper manufacturing methods. A 2015 study reported finding solvents such as 1,3-butadiene,
cyclohexane, and
acetone in e-liquids.
Contents The e-liquid is sold in bottles, pre-filled disposable cartridges, or as a kit for consumers to make their own e-liquids. E-liquids are made with various tobacco, fruit, and other flavors, Some flavors are created to resemble the flavors used in traditional cigarettes such as tobacco and menthol-tobacco. Adults in general also preferred sweet flavors (though smokers like tobacco flavor the most) and disliked flavors that elicit bitterness or harshness. In surveys of regular e-cigarette users, the most popular e-liquids had a nicotine content of 18 mg/ml, and the preferred flavors were largely tobacco, mint and fruit. The most favorite flavors among regular e-cigarette users reported in a 2017 UK survey were fruit, tobacco, and menthol/mint. The survey also found 2.6% regular e-cigarette users used no flavors. A 2013 study examined 33 countries and found that only 1% of the adult smokers exclusively used non-nicotine e-cigarettes. E-liquids are frequently sold in dropper bottles. One cartridge may typically last as long as one pack of cigarettes. A refill bottle can contain up to 100 mg/ml of nicotine, which is meant to be diluted before use. Some users, probably due to financial reasons and the willingness to experiment, are opting to make homemade e-liquids. A small percentage of liquids without flavoring is also sold. The flavorings may be natural or artificial. About 8,000 flavors existed in 2014. More than 15,500 flavors existed in 2018. A user does not normally consume a whole cartridge in a single session.
Standards E-liquid manufacturing requirements under the US
Food and Drug Administration (FDA) rules include report user fee information, pay user fees, register their establishment and submit list of products, including labeling and advertisements, submit health documents, submit ingredient listing, include required warning statements on packages and advertisements, submit quantities of harmful and potentially harmful constituents, and submit a modified risk tobacco product application. AEMSA has published a comprehensive list standards and best known methods, which are openly available for use by any manufacturer of e-Liquids. AEMSA guidelines recommend that the nicotine levels in e-liquids be within the amount of ±10% from the levels stated on the label.
Regulation Effective August 8, 2016, under the FDA rules, a company that mixes or prepares e-liquids is regulated as a tobacco product manufacturer. Companies who import or try to sell for import into the US must conform to the
Federal Food, Drug, and Cosmetic Act. The 2016 FDA ruling did not incorporate regulation concerning flavoring of e-cigarettes. Industry standards have been created and published by the American E-liquid Manufacturing Standards Association (AEMSA). The FDA has sought to regulate e-liquid in 2014 through use of the
Family Smoking Prevention and Tobacco Control Act, passed into law in June 2009. In April 2014, the FDA issued its "Deeming" proposals for public comment, which would cover e-liquids manufacturing. Manufacturers of e-liquid in the UK are required to inform the Government regarding the content in each liquid. The EU Tobacco Products Directive requires e-liquids to be tested 6 months before they are sold. The Tobacco Products Directive in the EU limits the sale of e-liquid. Refill liquids in the EU with more than 20 mg/ml of nicotine may be sold with prior authorization from the
pharmaceutical regulation.
Nicotine yield Smoking a traditional cigarette yields between 0.5 and 1.5 mg of nicotine, but the nicotine content of the cigarette is only weakly correlated with the levels of nicotine in the smoker's bloodstream. The amount of nicotine in the
e-cigarette aerosol varies widely either from puff-to-puff or among devices of the same company. E-liquids contain nicotine in a variety of different strengths, from no nicotine to 36 mg/ml. On average a regular cigarette contains 6–28 mg of nicotine or the user will inhale about 1.1 to 1.8 mg of nicotine if just a portion is used. On average an e-cigarette contains 0.5–15.4 mg of nicotine per 15 puffs. In practice, the nicotine concentration in an e-liquid is not a reliable guide to the amount of nicotine that reaches the bloodstream. == Notes ==