Capilouto served as
dean of the UAB School of Public Health from 1994 to 2001 before he returned to his research and faculty appointment as professor. He was named acting provost in 2002, and he assumed the post permanently in 2005. On May 4, 2011, Capilouto was selected to succeed
Lee Todd, Jr., the eleventh president of the University of Kentucky (UK). He was hired under a five-year contract with a base annual salary of $500,000, plus $125,000 in benefits and a possible bonus of up to $50,000. It prioritizes five principles: • Putting Students First • Taking Care of Our People • Inspiring Ingenuity • Ensuring Greater Trust, Transparency and Accountability • Bringing Together Many People; One Community Capilouto is committed to revitalizing the university's campus. Since he arrived, the university has invested $4 billion in infrastructure. In recent years, UK launched UK LEADS (Leveraging Economic Affordability for Developing Success) to retain students who would otherwise have to leave due to financial burdens. This innovative approach to recruitment and retention was awarded the EDGE Commendation for Innovation in Undergraduate Education. Capilouto announced the Kentucky Can Campaign in 2018 which has, in large part, funded this initiative. The Kentucky Can Campaign has raised more than $2.1 billion towards the university's endowment. Capilouto has emphasized the university's
land-grant mission as vital. In 2020, he established the vice president of land-grant engagement. This effort promotes engagement throughout campus and the state, particularly through its Cooperative Extension Service in all 120
Kentucky counties. The university's commitment to research and discovery grows every year. He designated eight research priority areas (Cancer; Cardiovascular Diseases; Diabetes & Obesity; Energy; Neuroscience; Substance Use Disorder; Diversity and Inclusion; and Materials Science) as a focused attempt to address Kentucky's biggest challenges. Under Capilouto's leadership the university and medical facilities have received many national awards and rankings. In 2023,
Forbes ranked UK as the best employer in Kentucky and ranked as the 6th best large employer in the nation. Additionally, in 2023, UK's Markey Cancer Center became the first and only
NCI-Designated Comprehensive Cancer Center in the state. Also, UK has been ranked in the top 30 of the
Directors’ Cup for 11 straight years (not including 2019–20). Leaning on his background in epidemiology and health policy and management, Capilouto in collaboration with the university's provost led the START (Screening, Testing and Tracing, to Accelerate Restart and Transition) Team. They worked intensely to reimagine UK's approach to education, research, service and care amidst the
COVID-19 pandemic. In January 2021, the START Team mobilized
Kroger Field as a
vaccine clinic administering nearly 250,000 doses. ==Controversy==