After college, Coupe took classes in improvisational comedy at
The Groundlings and
ImprovOlympic. In 2003, she toured France playing a soldier in an all-female version of
King Lear. In November 2005, her one-woman sketch show
The Patriots premiered at the
Upright Citizens Brigade Theatre in New York and won her the Breakout Performer Award at
HBO's
U.S. Comedy Arts Festival in
Aspen, Colorado in March 2006. In 2007, she appeared in
I Think I Love My Wife. She appeared in the short-lived MTV series
Short Circuitz. She was in "
Girlfriends", episode 8 of
the first season of
Flight of the Conchords; and in an episode of
Unhitched. She was a series regular in HBO's unaired
12 Miles of Bad Road and had a recurring role in
Samantha Who? She had a recurring role as Dr. Denise "Jo" Mahoney in
Season 8 of the TV series
Scrubs and the companion
web series Scrubs: Interns. She was made a regular in
Season 9, the final season of the series before it continued nearly sixteen years later. In March 2009, Coupe was cast as Callie in the
ABC pilot
No Heroics, an adaptation of the
UK series of the same name. In 2012, she played the female lead and love interest to
Daniel Henney in the independent film
Shanghai Calling, filmed in
Shanghai,
China. Coupe also starred as Tiger on the
Hulu comedy series
Future Man, which premiered November 14, 2017. The third and final season aired in 2020. In April 2020, she was cast as Amy in the
Fox comedy series
Pivoting. It debuted on January 9, 2022 with positive reviews, but the show was cancelled after one season. ==Personal life==