Cook moved to
Nashville, Tennessee in 1996 to work for
PricewaterhouseCoopers. She got a publishing deal and ended up sleeping on the floor of the publishing house for three years while she worked on honing her craft, with
The Blue Album, which contained demo recordings she had made in Nashville, finally being released in 2000. She cut her major-label debut, 2002's ''
Hey Y'all, for Atlantic Records. Hey Y'all'' was not a commercial success. After taking a shot at co-writing, Cook asked to be released from her contract. A proposed deal with
Sony Records subsequently fell through. She released 2004's
This Side of the Moon, which was eventually picked up by record label
Thirty Tigers. It received positive reviews from
The New York Times and
No Depression. Produced by
Rodney Crowell,
Balls, which included a song Cook had written with songwriter
Melinda Schneider, "Sometimes It Takes Balls to Be a Woman", was released in May 2007.
Welder featured appearances by
Dwight Yoakam, Crowell and
Buddy Miller. Cook toured in the United States, as well as in South Korea, Japan, Norway, Sweden, Poland, France and the UK. She appeared at the
Cambridge Folk Festival, the Maverick Festival and the Borderline in London. She has continued to play the
Grand Ole Opry, making over 400 appearances—the most by a non-member of the radio show. She toured the UK in support of
Welder, performing 18 dates with her then-husband, guitarist and songwriter Tim Carroll, and her upright bass player
Bones Hillman, formerly of
Midnight Oil. Cook was invited by the
Atlanta Braves to sing the
national anthem before their 2011 home opener on April 8, 2011. At the suggestion of
Paul Shaffer, Cook was invited in August 22 2011 to be a guest on
Late Show with David Letterman, where she discussed satellite radio and growing up in Florida. She considered starring in a
CBS sitcom about a single mother whose life is disrupted by the arrival of her criminal father, but the show never came to fruition. In June 2012 Cook returned to the
Late Show to perform with
Jason Isbell. They sang covers of
Townes Van Zandt's "
Pancho and Lefty" and "Tecumseh Valley". On March 14, 2013, she appeared a third time on the
Late Show with David Letterman and was interviewed by Letterman. She worked extensively with
Carlene Carter on Carter's tenth studio album,
Carter Girl. On June 2, 2014, she appeared a fourth time on
Late Show with David Letterman, performing
Lou Reed's "
Pale Blue Eyes". In 2016, Cook released her sixth studio album,
Exodus of Venus. In 2020, Cook began hosting
Upstream with Elizabeth Cook, a fishing show on the
Circle network. On September 11, 2020, she released the album
Aftermath. She can also be heard on select episodes of the
Adult Swim series
Squidbillies, where she voices Tammi. Cook hosts the mid-day radio show "Elizabeth Cook's Apron Strings" on the
Sirius XM radio station
Outlaw Country. She has been nominated for two Ameripolitan Music Awards for her radio work, including 2011, and she won their Outlaw Female award in 2014. ==Personal life==