Early career Fujino made her professional MMA debut at
Smackgirl-F: Next Cinderella Tournament 2nd stage & SG-F7 on , defeating Seri Saito by
unanimous decision. Fujino obtained her second victory by defeating Eri Takahashi with an
armbar submission in the second round on at
Cross Section. On at
Smackgirl 2006: Legend of Extreme Women, Fujino got her third straight win, defeating
Mai Ichii via unanimous decision. Fujino's fourth bout was a first round straight armbar submission victory over Madoka Okada at
Smackgirl 2007: Will The Queen Paint The Shinjuku Skies Red? on . Continuing her
winning streak, Fujino defeated Anna Saito via submission (
rear naked choke) in the first round on at the event
K-Grace. Fujino defeated Yukiko Seki via unanimous decision at ''Smackgirl 2007: Queens' Hottest Summer
on . At Cage Force EX: eastern bound
on , Fujino got her seventh consecutive victory when she faced and defeated Yuko Yamazaki via unanimous decision. In her next fight, Fujino defeated Mei Yamaguchi by split decision on at Smackgirl 7th Anniversary: Starting Over''. Ending Fujino's winning streak and breaking her undefeated record, women's MMA legend
Megumi Yabushita defeated Fujino by unanimous decision on at
Demolition 080721.
Valkyrie Debuting with promotion
Valkyrie at the promotion's first event
Valkyrie 01, Fujino was defeated by veteran Tomomi Sunaba via unanimous decision on . In a rematch of their 2007 bout, Mei Yamaguchi defeated Fujino by unanimous decision during Valkyrie women's featherweight tournament at Valkyrie 02 on . In her fourth consecutive loss, Fujino was defeated via
majority decision by Kyoko Takabayashi on at
Valkyrie 05. Fujino rebounded with a victory over Anna Saito in a rematch of their 2007 fight at
Valkyrie 08 on . Fujino choked Saito unconscious with a rear-naked choke in less than thirty seconds. Fujino faced
Megumi Fujii at World Victory Road Presents: Soul of Fight on and was defeated by unanimous decision.
Jewels Fujino made her
Jewels debut against Celine Haga at
Jewels 17th Ring on . She won the fight by unanimous decision. Fujino faced
Mika Nagano at
Jewels 18th Ring on . She won the fight by unanimous decision. Fujino challenged Jewels champion
Ayaka Hamasaki in a title fight at
Jewels 22nd Ring on in Tokyo. She was defeated by unanimous decision. On , Fujino made her
Pancrase debut at
Pancrase 247. She was scheduled to face Monica Lovato, but Lovato suffered an injury and Fujino instead faced Amber Brown. She defeated Brown by submission due to a neck crank in the second round. Fujino next faced Hyo Kyung Song at
Deep Jewels 1 on . She defeated Song by submission due to a rear-naked choke in the second round. In a rematch at
Deep Jewels 2 on , Fujino faced
Mizuki Inoue in the opening round of the Deep Jewels lightweight title tournament. She was defeated by unanimous decision. In her North American MMA debut, Fujino faced
Jessica Aguilar on June 21, 2014 at
World Series of Fighting 10: Branch vs. Taylor. She lost the fight via unanimous decision.
Deep Jewels and Road FC Returning to Japan, Fujino was scheduled to fight Ayaka Miura at
Deep - Jewels 6 on November 3, 2014. She won the fight by unanimous decision. Fujino was scheduled to face Emi Tomimatsu at
Deep - Dream Impact 2014: Omisoka Special on December 31, 2014. She won the fight by unanimous decision. Fujino made her
Road FC debut against
Jeong Eun Park at
Road FC 023 on May 2, 2015. She beat Park by majority decision. Fujino fought a rematch with
Mizuki Inoue at
Deep - Jewels 9 on August 29, 2015, for the Deep Jewels Strawweight Championship. Inoue successfully defended her title, winning the fight by unanimous decision. Fujino faced Nori Date at
Deep - Jewels 10 on November 23, 2015. She won the fight by first-round submission, locking in a rear naked choke after just 47 seconds. Fujino was scheduled to fight the future
UFC strawweight champion
Zhang Weili at Rebels 45 on August 7, 2016. Weili won the fight by a second-round TKO. Fujino faced another future
UFC strawweight,
Yan Xiaonan, at
Road FC 034 on November 19, 2016. Midway through the first round, an inadvertent clash of heads rendered Fujino unable to continue. The fight was accordingly called a no contest. Fujino was scheduled to face Natalia Denisova
Road FC 037 on March 11, 2017. She won the bout with a second-round rear naked choke. Back in Japan, Fujino faced Hyun Ju Baek at Deep 79 Impact on September 16, 2017. She won the fight by a first-round rear naked choke. Fujino was scheduled to fight Aline Sattelmayer at
Road FC 044 on November 11, 2017. She won the fight by unanimous decision.
Pancrase In early 2018, Fujino signed with Pancrase. She was scheduled to make her promotional return against
Sharon Jacobson at Pancrase 296 on May 20, 2018. She won the fight by unanimous decision. Fujino was scheduled to face the former Pancrase strawweight champion
Viviane Araújo at Pancrase 298 on August 5, 2018. Araújo won the bout by a third-round TKO. Fujino was scheduled to face Kseniia Guseva at Pancrase 304 on April 14, 2019. She won the fight by unanimous decision. Fujino fought Edna Oliveira Ajala at Pancrase 308 on September 29, 2019. Fujino was awarded a TKO victory at the end of the second round, as Ajala had to withdraw with a wrist injury. Fujino faced Hyun Ji Jang for the
Pancrase Women's Strawweight Championship at Pancrase 311 on December 11, 2019. She won the fight with a third-round rear-naked choke submission.
Rizin FF Fujino was scheduled to face
Ayaka Hamasaki on September 19, 2021 at
Rizin 30. She lost the fight by unanimous decision.
Loss of Pancrase title Fujino faced Karen in her first title defence of the
Pancrase Women's Strawweight Championship at Pancrase 326 on March 21, 2022. After being taken down in the 4th round and elbowed from mount, a cut was opened leading to excessive bleeding that resulted in the referee stopping the bout. Fujino was booked to face Song Hye Yun at Pancrase 329 on September 11, 2022. However the bout was scrapped after Song had visa issues and postponed till next month. The bout was supposed to take place at Pancrase 28th Neo-Blood Tournament Finals on October 9, 2022, but for unknown reasons Fujino faced
Ayaka Watanabe instead of Song Hye Yun. She won the fight via unanimous decision. Fujino faced Edna Trakinas at Pancrase 333 on April 30, 2023, losing the bout via unanimous decision. Fujino faced Shiho Mori on July 23, 2023 at Shooto 2023 Vol.5, submitting her via rear-naked choke in the first round. Fujino faced Momoka Hoshuyama on September 24, 2023, at Shooto 2023 Vol. 6, winning the bout via majority decision. Fujino faced Megumi Sugimoto on November 19, 2023 at Shooto 2023 Vol. 7, with the bout resulting in a
majority draw. ==Professional wrestling career==