He interned at
Firmin Desloge Hospital, now
St. Louis University Hospital in St. Louis, Missouri and served as a physician in the
Korean War. He worked at the
National Cancer Institute from 1955 to 1965 and the
M. D. Anderson Cancer Center from 1965 to 1972; while at M.D. Anderson he was the founding director of the Department of Development Therapeutics, which evolved into the Clinical Research Center. He served as physician-in-chief at the Dana-Farber Institute from 1972 to 1991. He is best known for his work on the treatment of lymphomas and childhood and adult leukemia. His groundbreaking research into then-controversial combination chemotherapy, including the
VAMP regimen, earned him many awards. He coauthored
Holland–Frei Cancer Medicine with
James F. Holland.
Involvement in Cancer Cooperative Group Research Frei was one of the founders of the Acute Leukemia Group B which later evolved into the
Cancer and Leukemia Group B (CALGB). He served as the group chair for 16 years, from 1956 to 1963, and again from 1981 to 1990.
Journal of Clinical Oncology He coined the
Journal of Clinical Oncology in 1981, journal published first issue in 1983 in association with American Society of Clinical Oncology. ==Recognition==