Mondonico began his managerial career with the Cremonese youth team in 1979. In 1982, he became manager of the senior team, and in 1984, achieved a historic promotion to Serie A with Cremonese. In 1987, he moved to
Atalanta, and guided them to the semi-finals of the
1987–88 European Cup Winners' Cup. In 1990, he joined
Torino, where he won the
Mitropa Cup over
Pisa and finished in fifth-place in the league during the
1990–91 season. En route to the final, Torino also overcame
Real Madrid in the semi-final. In the
1992–93 season, he won the
1993 Coppa Italia Final against
Roma. After a two-year spell with
Cosenza, he later joined
Fiorentina in 2003, and the following year, he led the club back into Serie A for the first time since their demotion to
Serie C2, following their bankruptcy in 2002; he subsequently had a stint with
AlbinoLeffe in Serie B in 2006, before returning to Cremonese the following year for a third time. He stepped down as head coach of AlbinoLeffe on 29 January 2011 due to "serious health issues", with his assistant
Daniele Fortunato taking over on an interim basis. Two days later, his club confirmed he had undergone abdominal surgery, expecting him to recover in a few weeks time. On 15 February, after a full recovery, Mondonico officially returned to his coaching duties at AlbinoLeffe. He guided AlbinoLeffe to narrowly escape relegation after defeating
Piacenza in the playoffs, but on 13 June he held an emotional press conference to announce that the illness had returned during the final period of the season and that he was seriously considering stepping down as a consequence. On 17 June 2011, Mondonico was confirmed to have resigned from AlbinoLeffe in order to focus solely on cancer treatment; he was replaced by his assistant Daniele Fortunato, who had already undertaken the first team coaching duties during his previous sick leave. On 30 January 2012, Mondonico marked his Serie A comeback, replacing
Attilio Tesser as head coach of
Novara, who were last-placed in the Italian top flight and seven points shy of relegation safety after the first half of the season. On 6 March 2012 he was sacked. ==Style of management==