In 2006 outgoing columnist
Margo Howard turned
Slates "
Dear Prudence" advice column over to Yoffe. The column appears four times per week, including one day of live chats and one day in which the letters are responded to using a video instead of text. In November 2015, Yoffe published her last "Dear Prudence" column, and was replaced by
Daniel M. Lavery, co-founder of
The Toast. Lavery left Dear Prudence in 2021. Yoffe also hosted a podcast called "Manners for the Digital Age" with
Slates then-technology columnist
Farhad Manjoo. She wrote a regular feature on
Slate called "Human Guinea Pig", in which she attempted unusual activities or hobbies. For "Human Guinea Pig", she has tried
hypnosis, and taken a
vow of silence. She has become a street performer, a nude model for an art class, and a contestant in the
Mrs. America beauty pageant. In June 2005,
Bloomsbury published Yoffe's
What the Dog Did: Tales from a Formerly Reluctant Dog Owner. That year it was named Best Book of the Year by Dogwise, and selected as the Best General Interest Dog Book by the
Dog Writers Association of America. She was a guest on
The Colbert Report twice. She discussed her experiences as ''Slate's
"Human Guinea Pig", and an article about narcissistic personality disorder. She has been a guest on numerous radio programs, including The Emily Rooney Show'' and Minnesota Public Radio. Yoffe has written pieces about the worldwide disappearance of frogs and the crash of
Air Florida Flight 90 for
The New York Times Magazine. She has written op-eds for
The Washington Post on
global warming, motherhood, and politics. As of December 2022, she is a writer for
The Free Press.
Writings on the Me Too movement and campus sexual assault Yoffe has written extensively about campus sexual assault and the Obama administration's effort to end it, describing the administration's reforms of
Title IX – the United States federal law prohibiting sex discrimination in federally-funded education programs – as a worthy goal that went awry. Her article in
Slate, "The College Rape Overcorrection" was a National Magazine Award finalist in Public Service in 2015. She wrote a series on campus sexual assault for
The Atlantic on due process,
junk science, and racial disparities. The series was a nominee for Top Ten Works of Journalism of the Decade by New York University's Arthur L. Carter Journalism Institute. She has praised the
Me Too movement; but expressed concerns about overreach. She wrote about "The Problem With #BelieveSurvivors", the consequences of
Al Franken's resignation from the Senate, and the dangers of "endlessly expand[ing] the categories of victim and perpetrator." She is a signer of
A Letter on Justice and Open Debate published in ''Harper's Magazine''. She is a member of the board of advisors of Persuasion.community, an organization that says it defends the ideals of a free society, for which she wrote "A Taxonomy of Fear", which describes her understanding of the term "
cancel culture".
Writings on transgender rights In March 2023, Yoffe interviewed whistleblower Jamie Reed for
The Free Press, whose claims that children were harmed through inadequate care at The Washington University Transgender Center at
St. Louis Children's Hospital have been disputed by several former coworkers and the parents of many patients. The claims are currently being investigated by The Washington University Transgender Center and the State of Missouri. In April 2023, Yoffe wrote an article interviewing a mother whose child received gender-affirming care from the Washington University Medical Center, claiming that the receipt of this care made her child's mental health deteriorate. A Twitter user saying they were the child has contradicted these claims on social media, saying that their deteriorating mental health at the time of receiving gender-affirming care had nothing to do with them being transgender and that they felt the article violated their consent. ==Books==