The Padroado Portuguese system which resented to the missionary works of
Propaganda Fide in India, arrested Ephrem in 1649, under the
Portuguese Inquisition and imprisoned him for about two years in Goa. By the grace of Bijapur Sultan, Ephrem was released from the Portuguese Inquisition in 1652. Ephrem de Nevers returned to his mission of Madras and served with a great missionary spirit and brought many souls to the Christian faith. In an Anglican colony, Father Ephrem lade a strong foundation for a Catholic faith in spite of the oppositions from the Anglican clergy. He founded a new church dedicated to Our Lady of Angels for the local converts at Armenian street in 1658, (this Capuchin church of St. Mary's served as the cathedral of Madras archdiocese from 1886-1952,today,
St.Mary's Co-Cathedral of Madras-Mylapore archdiocese and a famous shrine of St.
Anthony of Padua). He was always acclaimed a holy and saintly priest and lover of all who possessed the real missionary spirit. Having served 53 years as missionary in Madras, Ephrem de Nevers increased his flock from 40 to 8000 and he died on 13 October 1695 and he was buried in the church of St. Andrew in Fort St. George. when the English demolished this first church of Madras in 1752, the tomb of the first Christian missionary disappeared from the soil of Madras. ==Notes==