The diagnosis is made clinically, and usually this is clear cut if the lesion is associated with the flange of a complete denture. Tissue
biopsy is not usually indicated before removal of the lesion, since the excises surgical specimen is usually sent for
histopathologic examination and the diagnosis is confirmed retrospectively. Rarely, incisional biopsy may be indicated to rule out
neoplasia, e.g. in the presence of suspicious ulceration. The appearance may also be confused with
pyogenic granuloma. The excessive tissue is composed of cellular, inflamed fibrous connective tissue. The appearance of an epulis fissuratum microscopically is an overgrowth of
cells from the fibrous connective tissue. The
epithelial cells are usually hyperkeratotic and irregular, hyperplastic rete ridges are often seen.
Classification Epulis (literally, 'on the gingiva') is a general term for any
gingival or
alveolar tumor (i.e. lump on the gum). This term describes only the location of a lump and has no implication on the
histologic appearance of a lesion.
Epulis is also sometimes used synonymously with epulis fissuratum, however other conditions are classified as epulides, e.g. giant cell epulis (
peripheral giant cell granuloma), ossifying fibroid epulis (
peripheral ossifying fibroma), and
congenital epulis. ==Treatment==