Green Bay Packers St. Brown was selected by the
Green Bay Packers in the sixth round with the 207th overall pick in the 2018 NFL draft. He signed his rookie contract on May 7, 2018. St. Brown made his NFL debut in Week 1 against the
Chicago Bears on special teams. In a Week 5 loss to the
Detroit Lions, St. Brown recorded his first three professional catches, which went for 89 yards, including a 54-yard catch-and-run near the end of the game. On October 15 against the
San Francisco 49ers on
Monday Night Football, with 15 seconds left in the game, he recorded a key 19-yard catch that helped set up a game-winning
field goal by
Mason Crosby. St. Brown finished his rookie season with 21 receptions for 328 yards in 12 games and seven starts. During a preseason game against the
Oakland Raiders on August 22, 2019, St. Brown suffered a serious ankle injury, later reported to be a severe
high ankle sprain. The Packers placed him on
injured reserve on August 31, ending his 2019 season before it began. On September 19, 2020, St. Brown was placed on injured reserve. He was activated on October 17, 2020. On December 27, 2020, St. Brown caught his first NFL touchdown, a 21-yard reception from
Aaron Rodgers, during a 40–14 Week 16 victory over the
Tennessee Titans on
Sunday Night Football. In the 2020 season, St. Brown appeared in 12 games and started one. He finished with seven receptions for 117 yards and a touchdown. On August 31, 2021, the Packers waived St. Brown as part of their final roster cuts but was signed to the
practice squad the next day. On September 21, 2021, St. Brown was elevated to the active roster and sent back to the practice squad the next day. On October 3, 2021, St. Brown was once again elevated to the active roster and sent back to the practice squad two days later. On October 9, 2021, St. Brown was elevated to the active roster, and then reverted to practice squad again. Four days later the Packers signed him to the active roster. In the 2021 season, St. Brown appeared in 13 games and started two. He had nine receptions for 98 receiving yards.
Chicago Bears On March 18, 2022, St. Brown signed a one-year contract with the Bears. In the season opener against the 49ers, St. Brown scored a touchdown on an 18-yard pass from
Justin Fields. Coincidentally, his touchdown came two minutes after his brother,
Amon-Ra, scored a touchdown in the
Detroit Lions' opener. He finished the 2022 season with 21 catches for 323 receiving yards and one receiving touchdown in 16 games and starts. On January 4, 2023, St. Brown signed a one-year, $1.25 million contract extension with the Bears. In Week 4 against the
Denver Broncos, he made his season debut in place of benched
Chase Claypool. He was placed on injured reserve on October 13, 2023, with a hamstring injury. He was activated on November 9.
New Orleans Saints On April 12, 2024, St. Brown signed with the
New Orleans Saints. He was released on August 27, and re-signed to the practice squad.
San Francisco 49ers On July 22, 2025, St. Brown signed with the
San Francisco 49ers. On July 31, he was released by 49ers. St. Brown was re-signed by the 49ers on August 5, following the release of
Andy Isabella. On August 8, he was placed on the season-ending injured reserve list. On August 19, St. Brown was released by the 49ers with an injury settlement. ==NFL career statistics==