CSA and CSB proteins are thought to function in
transcription and
DNA repair, most notably in transcription-coupled nucleotide excision repair. CSA and CSB-deficient cells exhibit a lack of preferential repair of UV-induced
cyclobutane pyrimidine dimers in actively transcribed genes, consistent with a failed transcription coupled nucleotide excision repair response. Within the cell, the CSA protein localizes to sites of
DNA damage, particularly
inter-strand cross-links, double-strand breaks and some mono-adducts. ==Interactions==