Hipple was selected by the
Detroit Lions in the fourth round of the
1980 NFL draft. Hipple spent the 1980 season entirely on the bench while
Gary Danielson served as the starting quarterback. Hipple made his first appearance in a game in Week 5 (October 4) of the following season, throwing 4-of-15 for 102 yards and two interceptions in a loss. After the first six weeks had ended, Hipple was tapped to start against the Chicago Bears on October 19 due to Danielson suffering an injury, which resulted in him going 14-of-25 for 336 yards to go along with four passing touchdowns and two rushing touchdowns in a 48-17 victory where he threw just four total passes in the second half. The jersey worn by Hipple from that game was collected by the
Pro Football Hall of Fame. He would start the remainder of the season, going 6-4 as a starter as Detroit finished 8-8; he threw 2,358 yards with 14 touchdowns to 15 interceptions with a passer rating of 73.4. In the strike-shortened 1982 season of nine games, Hipple started the first four games while Danielson started the last five as Detroit made the postseason in an eight-team NFC playoff bracket. For the postseason game against the Washington Redskins, Hipple was tapped to start the first playoff game for the team since 1970. He went 22-of-38 for 298 yards with one touchdown and two interceptions (one returned for a touchdown by
Jeris White) as Detroit lost 31-7 in a game where they trailed 10-0 from the first quarter on. Hipple was the undisputed starter for the 1983 season, and he threw for 2,577 yards with 12 touchdowns and 18 interceptions as the Lions went 9-7 but Hipple suffered moderate tear of his left knee ligament against Tampa Bay in the season finale (which meant he would be out for roughly 2-6 weeks) that resulted in Danielson serving as the starter for the Divisional Round playoff game against the
San Francisco 49ers, which Detroit narrowly lost. Hipple played in just two games of the 1984 season due to knee issues. The team signed him to a two-year contract on March 26, 1985. Hipple would start the first fifteen games of the 1985 season before being used in relief for the finale that ultimately saw the Lions go 7-9 while he passed for 2,952 yards with 17 touchdowns to 18 interceptions. Hipple started the first ten games of the 1986 season, which saw them win just three games before
Joe Ferguson and
Chuck Long finished out the season. He threw for 1,919 yards with nine touchdowns to 11 interceptions. Hipple had 63% of his passes (192-for-305) result in a completion to lead the NFL. He was the first Lion to lead in completion percentage since
Bobby Layne in 1955 and is currently the last Lion to finish as a leader. The following month, on November 7, 1989, the Lions cut him from the roster, which now had
Bob Gagliano and
Rodney Peete start games. The game against the Vikings was the last one that the 32-year-old played in. In total, Hipple made appearances in 102 games (with 57 starts) and threw for 10,711 total yards and 55 touchdowns to 70 interceptions. He went 28-29 as a starter. ==Career statistics==