Rhodes has been a frequent guest on
A Prairie Home Companion since her first appearance in 1996 where she initiated her recurring role as "The Conscience" of the host, Garrison Keillor. She appears on Keillor's 1997
Grammy-nominated album
Garrison Keillor’s Comedy Theatre. In 2008, Rhodes had a leading role in the independent
horror film Plague Town. Rhodes released her first
comedy album,
Sad Lemon, on June 29, 2019. The same year, she competed on the
NBC comedy competition series
Bring the Funny. In 2021, Rhodes released the comedy special
La Vie en Rhodes, filmed outside the
Rose Bowl in
Pasadena, California, during the
COVID-19 pandemic. The same year, she voiced the character of Dotty on the animated
Netflix series
A Tale Dark & Grimm. In 2024, Rhodes competed on the series ''
America's Got Talent''. ==Podcast and radio appearances==