The Schuman lab studies the properties of mRNAs and proteins (e.g. the
transcriptomes and
proteomes) distributed throughout the neuron. Her research has examined how stability in neuronal processes can be brought about by local cell biological processes, like protein synthesis, allowing synapses to respond rapidly and appropriately to changing stimuli. The Schuman lab demonstrated the first functional role for local translation in neurons. In 1996, in the course of exploring how
neurotrophins enhance synaptic transmission, Schuman together with graduate student Hyejin Kang made the discovery that local protein synthesis within
dendrites is required for this form of
synaptic plasticity. She obtained direct proof that protein synthesis occurs in intact, isolated dendrites. This, together with a few other key observations, gave birth to the field of local translation. Her team discovered, using next generation sequencing, over 2500
mRNAs localized to the
neuropil. In addition, Schuman and collaborators (Dave Tirrell, Caltech and Daniela Dieterich, Magdeburg) has made invaluable technical contributions, such as the development of non-canonical amino acid metabolic labelling, click chemistry, and mutation of cell-biological enzymes (the BONCAT and FUNCAT techniques), enabling the labelling, purification, identification and visualization of newly synthesized proteins in neurons and other cells. ==Advocacy for women in neuroscience==