Much of Lesky's early work in the
Institute for the History of Medicine involved rebuilding the institute, both intellectually and physically, after its deterioration during and after World War II. Although her doctoral research had concerned medicine in ancient Greece, her scholarly work from this period shifted in focus to the history of medicine in Austria. She published her first monographs on this topic in the late 1950s. In 1960 she translated an English-language work of
Johann Peter Frank into German, and was the editor of an autobiography of
Carl von Rokitansky; later she also edited Frank's autobiography, and translated a book of selected works of Frank from German into English. She published three monographs on the Viennese Medical School in 1964, 1965, and 1981, the second of which was translated into English in 1976. Another 1970 monograph concerned Czech physician
Jan Evangelista Purkyně, and a monograph from 1979 concerned German phrenologist
Franz Joseph Gall. She worked as a de facto editor for the book series
Clio Medica beginning in 1964, and served as its official editor from 1970 to 1974. ==Recognition==