Mario was a registered pharmacist in the
State of New York and worked as a community pharmacist during his early career. After completing his graduate work, he began a career in the pharmaceutical industry, beginning as a researcher for Strasenburgh Laboratories in
Rochester, New York. He subsequently held positions with SmithKline & French in Philadelphia, PA; E.R. Squibb & Sons in New Brunswick, NJ and Princeton, NJ; and Glaxo Inc. in Research Triangle Park, North Carolina. He was the chairman and CEO of Alza Corporation, based in
Palo Alto, California, from 1993 until the company was purchased by
Johnson & Johnson, Inc., in 2001. After Alza, Mario became chairman and CEO of Reliant Pharmaceuticals, based in
Liberty Corner, New Jersey. He was also the non-executive chairman of Pharmaceutical Product Development, Inc, based in
Wilmington, North Carolina, from 1993 to 2009. In April 2010, he was appointed to the board of directors for Vivus Pharmaceuticals. He has served on numerous other public corporate boards, as well as several non-profits. ==Trustee of Duke University==