On February 14, 1970, Lopez got a shot at the world welterweight boxing title in a bout against
Cuban Jose "Mantequilla" Nápoles in front of a sellout crowd at
The Forum in
Inglewood, California. Lopez was knocked down in the 1st, 9th, and 15th rounds before the bout was called as a
technical knockout in the 15th round. In 1971, boxing writer Dan Hafner said of Lopez: It is the misfortune of Ernie (Indian Red) Lopez to come along when one of the all-time greats, José Nápoles, rules the welterweight division. The fiery, part-Ute Indian demonstrated beyond doubt on Thursday night that he is the class of the rest of the 147-pounders. In his smartest and possibly best fight of his career, Lopez pounded out a unanimous, one-sided 10-round decision over highly regarded
Oscar Albarado and gave a masterful performance.
Sugar Ray Leonard, who watched Nápoles fight Lopez, shared a similar opinion, "If it wasn't for Nápoles, Ernie probably would have been champion." Lopez got a rematch against Nápoles, and a second shot at the title, three years later on February 28, 1973—again in front of a sellout crowd at The Forum. The second bout proved to be a turning point in Lopez's life. Lopez had reportedly won the first six rounds, and Nápoles had cuts above and below his eye and on the bridge of his nose. At the start of the seventh round, Nápoles hit Lopez squarely in the face, and Lopez fell to the canvas, where he lay unconscious for three minutes. After the knockout, Nápoles cradled Lopez's head and repeated, "Please wake up. Please wake up." ==Wanderer and missing person==