Groningen Van de Looi started his coaching career as head coach of FC Groningen U21 in 2008. Two years later, he became assistant manager of FC Groningen. On 4 April 2013, it was announced that Van de Looi would become the new manager of the FC Groningen first team for the 2013–14 season, signing a two-year contract. During the 2014–15 season, Van de Looi led FC Groningen through their most successful ever
Dutch Cup campaign as they won it for the first time in the club's history by defeating cup holders PEC Zwolle 2–0 in the final. By winning the Dutch Cup, FC Groningen qualified for the
2015–16 UEFA Europa League group stages. On 27 January 2016, it was announced that Van de Looi would leave the club at the end of the season.
Willem II On 23 May 2016, Van de Looi was announced as the new manager of Dutch football club
Willem II, signing a two-year contract. Before the end of the season and his contract at Willem II, supporters demanded the leave of Van de Looi through a
manifesto. On 8 March 2018, Van de Looi decided to leave the club.
Netherlands U21 On 21 May 2018, Van de Looi was announced as the new manager of the
Netherlands national under-21 football team, signing a contract until the end of 2020 with the contract automatically being extended until the summer of 2021 if the Netherlands qualifies for the 2021
UEFA European Under-21 Championship. Van de Looi took over after
Art Langeler, who moved to the position of Director of Football Development for the
KNVB. In August 2020, Van de Looi was temporarily added to the staff of the
Netherlands national team. The U21 would be temporarily coached by
Marcel Groninger, his assistant.
Heracles Almelo On 21 December 2023, Heracles Almelo appointed Van de Looi as the new head coach, replacing
John Lammers. He left the club at the end of the
2024–25 season, after opting not to renew his contract. ==Honours==