Team changes Sixteen teams compete in the season: 11 teams from the previous División Intermedia season plus the two teams relegated from the División de Honor in its
2025 season (
General Caballero (JLM) and
Tembetary), the 2025 Primera B Metropolitana champions
Benjamín Aceval,
Paraguarí Atlético Club, who were established as a club from the team representing the Paraguarí football league which won the 2024–25
Campeonato Nacional de Interligas, and the Primera B Metropolitana runners-up
3 de Noviembre, who defeated the 2025 Primera B Nacional champions 15 de Mayo from
Itapé in a promotion play-off series. These teams replaced
Rubio Ñu and
San Lorenzo, both promoted to the top flight at the end of the previous season, as well as
River Plate,
Pastoreo, and
Guaraní de Fram, who were relegated to the third-tier leagues.
Stadia and locations ;Notes ==Standings==