In September 1757, Aaron Burr Sr. died of a fever in
Princeton. Esther's father, Jonathan Edwards, came to Princeton to be Burr's successor as president of the college, but died on March 22, 1758, from complications following a
smallpox inoculation. Barely a fortnight after the sudden death of her father, Esther also fell ill and died on April 7, 1758, after "a few days illness". She was seized with a fever, apparently not linked to her recent smallpox inoculation, which produced a violent
headache and then
delirium. Her sister Sarah believed it was not unlike the sudden fever from which her sister Jerusha had died. Esther's death left her two children, Aaron and Sarah Burr, as orphans. Aaron and his sister went to live with their wealthy maternal uncle Timothy Edwards in a cramped, crowded environment.
Sarah Edwards, Esther's mother, died soon after in October 1758. Esther, along with the rest of the Edwards family, were buried together at the Bridge Street Cemetery in Northampton. Sarah Prince was nearly inconsolable by Esther's death. In her personal book of meditations, she wrote, "My whole dependance for Comfort in this World [is] gone...", and "[Esther] was dear to me as the Apple of my Eye- she knew and felt all my griefs..." ==In popular culture==