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Estrogen-related receptor gamma

Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3, is a nuclear receptor that in humans is encoded by the ESRRG gene. It behaves as a constitutive activator of transcription.

Bisphenol A binding
There is evidence that bisphenol A functions as a xenoestrogen by binding strongly to ERR-γ. BPA binding to ERR-γ preserves its basal constitutive activity. Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta, explaining reports of high bisphenol A accumulation there. == References ==
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