Ethylestrenol

Ethylestrenol has been used for a variety of indications including: • As an adjunct for catabolic states such as corticosteroid therapy and convalescence as in chronic infections, extensive surgery, and severe trauma ==Contraindications==

Ethylestrenol should not be taken by pregnant women as it can masculinize female fetuses. ==Side effects==

Side effects of ethylestrenol include virilization among others. ==Pharmacology==

Pharmacodynamics (3-ketoethylestrenol), the active metabolite of ethylestrenol. As an AAS, ethylestrenol is an agonist of the androgen receptor (AR), similarly to androgens like testosterone and dihydrotestosterone (DHT). It has low estrogenic activity (via aromatization into ethylestradiol following transformation into norethandrolone), strong progestogenic activity, and a high ratio of anabolic to androgenic activity, similarly to other nandrolone derivatives. It is known to be metabolized into the closely related AAS norethandrolone (17α-ethyl-19-nortestosterone) in the body and has been regarded as a prodrug of norethandrolone. ==Chemistry==

Ethylestrenol, also known as 3-deketo-17α-ethyl-19-nortestosterone or as 17α-ethylestr-4-en-17β-ol, is a synthetic estrane steroid and a 17α-alkylated derivative of nandrolone (19-nortestosterone; 19-NT). It is specifically the 17α-ethyl and 3-deketo derivative of nandrolone as well as the 3-deketo derivative of norethandrolone (17α-ethyl-19-NT). Other related AAS include bolenol (3-deketo-17α-ethyl-19-nor-5-androstenediol), ethyldienolone (17α-ethyl-δ9-19-NT), norboletone (17α-ethyl-18-methyl-19-NT), propetandrol (17α-ethyl-19-NT 3β-propionate), and tetrahydrogestrinone (THG; 17α-ethyl-18-methyl-δ9,11-19-NT). The progestins allylestrenol (3-deketo-17α-allyl-19-NT) and lynestrenol (3-deketo-17α-ethynyl-19-NT) are also closely related to ethylestrenol, differing only by the C17α substitution. ==History==

Ethylestrenol was described in the literature in 1959 and approved for medical use in 1961 and in the United States in 1964. ==Society and culture==

Generic names Ethylestrenol is the generic name of the drug and its , , and , while éthylestrénol is its and ethylnandrol is its . The was formerly ethyloestrenol, but it was eventually changed. == References ==