After a post-doctoral fellowship and assistant adjunct professorship at the University of California, San Francisco, Harris joined the faculty at UC Berkeley. There, she developed a multidisciplinary approach for studying the
virology,
pathogenesis, and
epidemiology of
dengue fever, the most prevalent mosquito-borne viral disease in humans. Harris' lab studies the mechanism of dengue virus infection of human
dendritic cells. The lab is also developing a mouse model to study viral
tropism and the
immune response to dengue virus infection, to generate a better model of the disease. Harris' fieldwork focuses on
molecular and
epidemiological field studies of dengue in endemic Latin American countries, particularly in
Nicaragua. Ongoing fieldwork projects include clinical and biological studies of severe dengue, a pediatric
cohort study of dengue transmission in
Managua, and a project on evidence-based, community-derived interventions for prevention of dengue via control of its
mosquito vector. Harris is currently initiating studies of dengue
pathogenesis in humans, focusing on functional characterization of antibodies and B cell memory response, host gene expression profiling, and viral factors such as
quasispecies. Harris is also collaborating with investigators at the
UC Berkeley College of Engineering to develop the ImmunoSensor: a novel, rapid, low-cost diagnostic device for point-of-care diagnosis of dengue and other
infectious diseases. She served as co-director of the "International Training and Research in Emerging Infectious Diseases" program at the
Fogarty International Center from 1997 to 2003. In 2010, Harris entered into a research agreement with
NanoViricides, Inc. (NNVC). She has published over 150 peer-reviewed articles. ==Humanitarian work==