During her post-doctoral work in the laboratory of Ken Downing at the
Lawrence Berkeley National Laboratory, Eva Nogales was the first to determine the atomic structure of
tubulin and the location of the taxol-binding site by
electron crystallography. She became an assistant professor in the Department of Molecular and Cell Biology at the
University of California, Berkeley in 1998. In 2000 she became an investigator in the
Howard Hughes Medical Institute. As
cryo-EM techniques became more powerful, she became a leader in applying cryo-EM to the study of microtubule structure and function and other large
macromolecular assemblies such as
eukaryotic transcription and translation initiation complexes, the polycomb complex PRC2, and
telomerase. ==Selected publications==