House describes Wilson as "a buddy of mine people say 'Thank you' to when he tells them they are dying." House also describes Wilson as an "emotional vampire". On a date with Dr.
Lisa Cuddy (
Lisa Edelstein), Wilson evades a question as to whether or not he wants children. Wilson is also seen to write with his left hand, a trait he shares with Cuddy and Foreman, but when he performs detailed medical work, such as injections or incisions, or gesticulates while speaking, appears to be right-handed in general, suggesting he may be ambidextrous. Wilson attempts to change House's drug habits, with little success. After Cuddy makes a bet to prove House is addicted to
Vicodin, House concedes to Wilson that he has an
addiction but says that the addiction is not a problem. It is, in fact, Wilson who usually writes House's
Vicodin prescriptions (with Cuddy writing a few merely for leverage in her dealings with House). In Season 3, when Detective
Michael Tritter (
David Morse) threatens to jail House for his Vicodin addiction after finding a huge stash in his apartment, Wilson attempts to convince House to go to
rehab as the situation worsens. After Tritter pressures Wilson to testify several times, Wilson reluctantly agrees, unknown to House. Before this, Wilson watches House punch Dr.
Robert Chase, insult Cuddy, and incorrectly diagnose a child with a condition that would have required the
amputation of her left arm and leg. Near the end of Season 4, Wilson starts a romantic relationship with
Amber Volakis, who shares many character traits with House, and who competed for one of the open jobs on House's team in the wake of Foreman, Chase, and Cameron's departure. In the Season 4 finale, she dies after a bus crash sustained while picking up a drunken House from a bar. Her death eventually leads Wilson to conclude that his relationship with House serves to enable House's dysfunctions. To remove himself from House's influence, he resigns from Princeton-Plainsboro at the beginning of Season 5. The two reconcile when Wilson forces House to attend the funeral of House's father. Wilson realizes that he had been afraid of losing House, who is his true friend, and that Wilson's life didn't get any better when he resigned. He then returns to Princeton-Plainsboro. In addition, Wilson proposes a joke marriage to House in "
The Down Low". Gay references have been made to the relationship between the two characters of the show. House jokes about their relationship, stating "I'm gay!...Oh that's not what you meant. It would explain a lot, though: no girlfriend, always with Wilson, the obsession with sneakers..." Barbara Barnett said that "House is the needy one in the relationship, and Wilson the doormat". However, Robert Sean Leonard compared the relationship between the two to that of
Cesar Millan and his
Pit Bull, while
Hugh Laurie said that it's "not just buddydom". The two characters appeared on the October 13, 2008, cover of
TV Guide. == Concept and creation ==