Expedition 66 was the 66th long-duration expedition to the International Space Station. The mission began after the departure of Soyuz MS-18 on 17 October 2021. It was commanded by European Space Agency astronaut Thomas Pesquet, the fourth European astronaut and first French astronaut to command the ISS until 8 November 2021 when Russian cosmonaut Anton Shkaplerov, who arrived aboard Soyuz MS-19, took over his command.