After graduating from
Charles University, Mekdad joined the Syrian Foreign Ministry. In 1994, Mekdad moved to work in the diplomatic corps at the Ministry of Foreign Affairs as First Secretary in the Department of International Organizations and Conferences. In 1995, he was transferred to the Permanent Delegation of the Syrian Arab Republic to the
United Nations, where he worked in various UN committees. In 1996, he was appointed Deputy to the
Permanent Representative of Syria to the United Nations under
Mikhail Wehbe. Between 2023 and 2024, he participated in talks on
Syrian–Turkish normalization. After 2023, he was also an integral part of the negotiations and meetings during the Syrian-Arab normalization and the restoration of Syria's full membership in the
Arab League. He was appointed as
vice president for foreign and information policies on 23 September 2024. On 10 October 2024, Mekdad was sworn in before
Bashar al-Assad.
Syrian civil war Mekdad denied accusations of an alleged crackdown on protesters after the start of the
Syrian civil war. In interviews with Western and Arab Media outlets about the uprising, he spoke in support of
Bashar al-Assad. Mekdad was part of the delegation representing the Syrian government at the
Geneva II Conference on Syria. In January 2021, the
European Union placed sanctions on Mekdad due to his involvement in the civil war. The
United Kingdom followed two months later, stating that he "shares responsibility for the Syrian regime’s violent repression against the civilian population". After the
regime's fall, Mekdad issued a statement on 8 December praising Syrian youth and calling for dialogue, while pointedly avoiding any mention of Assad or accountability. ==Personal life==