,
Rita Volk,
Katie Stevens,
Gregg Sulkin and
Michael J. Willett Main cast •
Rita Volk as Amy Raudenfeld, a junior at Hester High School and Karma's cynical best friend. She hesitantly agrees to Karma's plan of pretending to be lesbians for popularity, but realizes she might not actually be "faking it" after their first kiss, and, as their lie progresses, so do her romantic and sexual feelings for her best friend. Although, at first, she is not sure whether she is a lesbian, or solely attracted to Karma, she eventually decides she must move on and begins dating girls, even beginning a serious relationship, and is confused and angered by Karma's apparent jealousy. Amy also has issues with her conservative, former beauty queen mother, who has a hard time dealing with her daughter being bisexual, and who connects more to Amy's stepsister. •
Gregg Sulkin as Liam Booker, Shane's best friend, a mysterious and sexy artist who is the most desired boy at the school, and becomes secretly involved with Karma. At first, he is only attracted to her because of his desire to have sex with a lesbian, but he quickly realizes that he has developed real feelings for her. •
Michael Willett as Shane Harvey, the most popular boy in school who is openly gay. He is witty, straightforward and outgoing, and the best friend of both Liam and Amy. It is Shane who initially (erroneously) outs Karma and Amy as lesbians. He is also who brings attention to Lauren being intersex, when he publicly confronts her after hearing that she secretly takes pills, drawing attention to her situation, unaware of her need to take hormones. Shane becomes Amy's confidant as her feelings towards Karma develop. By of the end of the series, he has had three major love interests: a celibate Christian named Pablo; a closeted, macho wrestler named Duke, who eventually comes out to please Shane but dumps him when he learns Shane is the one who outed him in the first place; and Noah, a trans man who Shane feels conflicted about being attracted to due to the gender he was assigned at birth. •
Bailey De Young as Lauren Cooper, Amy's stepsister, and the new girl in school. Highly conservative, she is furious and frustrated, aware that someone like her would almost certainly be highly popular in a "normal" school that didn't have such liberal-minded students. In season 2, it is revealed that she is
intersex, initially a secret shared only with close friends. She faces stress as more and more students find out. Lauren becomes very close with her new stepmother, Amy's mom, after realizing they enjoy the same things, and that she relates more to her than with anyone at her school.
Recurring cast Introduced in season 1 •
Rebecca McFarland as Farrah, Amy's mom, a local television reporter who holds conservative views and is shocked to learn of Amy's sexual orientation •
Senta Moses as Penelope Bevier, the principal of Hester High, later vice-principal after the school drug bust • Erick Lopez as Tommy Ortega, Lauren's boyfriend • Courtney Kato as Leila, a friend of Lauren's • Breezy Eslin as Elizabeth, a friend of Lauren's • Anthony Palacios as Pablo, Lauren's dance partner and Shane's ex-boyfriend •
Amy Farrington as Molly, Karma's mother •
Lance Barber as Lucas, Karma's father •
Dan Gauthier as Bruce Cooper, Lauren's father •
Courtney Henggeler as Robin Booker, Liam's sister • August Roads as Oliver Walsh, a friend of Amy's
Introduced in season 2 •
Yvette Monreal as Reagan, Amy's ex-girlfriend •
Keith Powers as Theo, a friend of Liam and Shane's and Lauren's love interest •
Bruce Thomas as Max Booker, Liam's adoptive father • Skyler Maxon as Duke Lewis Jr., Shane's ex-boyfriend •
Chloe Bridges as Zita Cruz, a friend of Liam's •
Bernard Curry as George Turner, the new principal of Hester High following the school drug bust •
Parker Mack as Felix Turner, a student at Hester High and the son of Principal Turner •
Ed Quinn as Hank, Amy's father •
Cameron Moulène as Wade, the show's first bisexual identified character •
Lindsey Shaw as Sasha Harvey, Shane's older sister
Introduced in season 3 •
Jordan Rodrigues as Dylan, Karma's Hawaiian boyfriend, whom she met while lifeguarding over the summer •
Elliot Fletcher as Noah, the show's first
transgender-identified character, who is a member of the band Noah's Arc, and is a love interest of Shane's •
Sophia Ali as Sabrina, a childhood friend and love interest of Amy's •
McKaley Miller as Rachel, Liam's coworker and love interest, and the daughter of a rabbi •
Alice Lee as Keiko Flynn, a friend of Lauren's
Guest cast •
Austin Lyon as Victor •
Jacquie Lee as herself •
Laverne Cox as Margot •
Fifth Harmony as a girl group •
Mary Lambert as herself •
Sofia Carson as Soleil •
Nicholas Brendon as Jackson Lee ==Broadcast==