Voice cast •
Michael J. Fox as Stuart Little, a young
anthropomorphic mouse adopted as part of the Little family. •
Melanie Griffith as Margalo, a young anthropomorphic
yellow canary whom Stuart meets on his way home from school and becomes his love interest, though it is revealed that she is actually in cahoots with Falcon. •
James Woods as Falcon, a
peregrine falcon who served as Margalo's master as well as being the main
antagonist. •
Nathan Lane as Snowbell, the family's
Persian cat who is Stuart's best friend. •
Steve Zahn as Monty, a gray
tabby cat who is Snowbell's best friend.
Live-action cast •
Geena Davis as Mrs. Eleanor Little, the
matriarch of the Little family and Frederick's wife. •
Hugh Laurie as Mr. Frederick Little, the
patriarch of the Little family and Eleanor's husband. •
Jonathan Lipnicki as George Little, the eldest son of the Little family and Stuart's older brother. • Anna and Ashley Hoelck as Martha Little, the infant daughter of the Little family and Stuart and George's younger sister. •
Marc John Jefferies as Will Powell, George's loyal best friend. •
Jim Doughan as Stuart and George's soccer coach. Doughan previously voiced Lucky and played the role of Detective Allen in
Stuart Little. •
Brad Garrett as Rob, a
plumber called to find Eleanor's ring in the kitchen sink's pipes. •
Amelia Marshall as Rita Powell, Will's mother. •
Ronobir Lahiri as the unnamed
Indian-American taxi driver •
Maria Bamford as Stuart and George's teacher • Angelo Massagli as Wallace, one of Stuart and George's soccer teammates. • Kevin Olson as Irwin, another of Stuart and George's soccer teammates. ==Production==