Familial osteodysplasia, Anderson type

People with this disorder often show the following symptoms: Craniofacial • Underdevelopment of midface • Flat, broad nasal bridge • Thin, prognathic mandible • Pointy chin • Malocclusion • Underdeveloped teeth Skeletal • Scoliosis • Thinning of the calvaria • Pointy spinous processes • Clinodactyly • Phalangeal dysplasia Additional symptoms include hyperuricemia, high erythrocyte sedimentation rates and hypertension. == Etymology ==

This condition was first discovered in 1972 by L G Anderson et al. and J S Buchignani et al. They described the case of five siblings and their dad; four out of the five siblings had recurrent mandibular fractures and cranio-facial dysmorphisms, such as prominent earlobes. These four siblings also had hyperuricemia and three out of those four siblings had hypertension. Their father had hyperuricemia and hypertension but was otherwise unaffected. The siblings were the result of consanguineous Irish parents. == References ==