The club was founded in 1960 under the name
Bukhoro. In 1989 the club was renamed to
Nurafshon. During the 1990 season the club played in the Soviet Second League, zone "East", finishing in 4th position. Buxoro played its first
Oliy League season in 1992. Their best performance in
Oliy League is runners-up of the
1994 season to
Neftchi Farg'ona. FK Bukhoro played three times in semi-final of Uzbek Cup. In the 2005 Cup semi-final the club lost to
Neftchi Farg'ona in two legs by 1–3 and in 2012 lost to
Nasaf with a 3–5 score. After the 2013 season had finished, on 10 November 2013
Edgar Gess became new head coach of Bukhoro, replacing
Tachmurad Agamuradov in this position.
Name changes • 1960–67: FC Bukhoro • 1967–80: Fakel Bukhoro • 1980–88: FC Bukhoro • 1989–97: Nurafshon Buxoro • 1997–2021: FK Buxoro • 2021 (since September): Nurafshon Buxoro • 2022–: FK Buxoro
Domestic history ==Honours==