First term (1949–1953) In 1949, Lopez became vice-president under President
Elpidio Quirino and concurrently worked as secretary of agriculture, serving until 1953. He was then elected once again as senator, and re-elected in 1959.
Second and third term (1965–1972) at the Presidential study. In 1965, Lopez ran with
Ferdinand Marcos and won as vice president. He was re-elected in 1969, making him to date the only vice president to serve two non-consecutive terms, with two different presidents and from different parties. By the time
martial law was declared in 1972, the Lopez family fell out of Marcos' favor and was targeted by the regime because of their denunciations of Marcos. The office of vice president was abolished, and the Lopez family was stripped of most of its political and economic assets. ==Later life and death==