On 25 June 1647, Ferrante married Princess Margherita
d'Este (1619-1692), daughter of Duke
Alfonso III d'Este of
Modena. They had: • Isabella (d. 1653). • Rinaldo (1652 – 9 October 1657). • Cesare (1653–1666). •
Anna Isabella (12 February 1655 – 18 August 1703), married in 1670
Ferdinando Carlo Gonzaga (1652–1708), Duke of Mantua and Monferrato. • Maria Vittoria (9 September 1659 – 5 September 1707), married in 1679 her cousin
Vincenzo Gonzaga. • Vincenzo (d. 1665/66). When Ferrante died without surviving male heirs, the Duchy of Guastalla became officially a part of the
Duchy of Milan. It was ruled by his daughter Anna's husband, Ferdinando Carlo of Mantua from 1678 to 1692. Due to Austrian intervention, the Duchy then passed to his daughter Maria's husband, Vincenzo Gonzaga. ==References==