Main •
Gary Oldman as Jackson Lamb, the head of Slough House who is unkempt, flatulent, and rude with a sour wit, all disguising a tactical sharpness and firm loyalty to his agents, who he refers to affectionately as "Joes". •
Jack Lowden as River Cartwright, an up-and-coming MI5 agent abruptly shunted to Slough House after a very public training-exercise blunder. •
Kristin Scott Thomas as Diana Taverner, the power-hungry Deputy Director General of MI5 and head of operations, designated "Second Desk" until the end of series 5 when promoted to "First Desk", Director General of MI5. •
Jonathan Pryce as David Cartwright (series 4 – present; special guest series 1–3), River's grandfather, a retired senior MI5 officer with a legendary reputation, often known as "The Old Bastard". •
Hugo Weaving as Frank Harkness (series 4 and 6), a former
CIA operative turned ruthless mercenary. He is later revealed to be River's biological father. •
Saskia Reeves as Catherine Standish (series 5 – present; co-starring series 1–4), Slough House's office administrator, a recovering alcoholic, and still enamoured with her long-deceased superior. •
Rosalind Eleazar as Louisa Guy (series 5 – present; co-starring series 1–4), assigned to Slough House after a tail operation went badly wrong. •
Christopher Chung as Roddy Ho (series 5 – present; co-starring series 1–4), an arrogant and obnoxious computer nerd and former
hacktivist with undeniable technical skills. •
Aimee-Ffion Edwards as Shirley Dander (series 5 – present; co-starring series 2–4), a physically capable agent undone by drug and anger issues.
Special guests •
Sophie Okonedo as Ingrid Tearney (series 1 and 3), the Director General of MI5, often referred to as "First Desk". •
Katherine Waterston as Alison Dunn (series 3), an MI5 agent who uncovers a dark secret at the heart of the agency. •
Sope Dirisu as Sean Donovan (series 3), a former head of security at the British embassy in Istanbul.
Slough House •
Dustin Demri-Burns as Min Harper (series 1–2), assigned after absent-mindedly leaving a top-secret disk on the train. •
Olivia Cooke as Sidonie "Sid" Baker (series 1), a competent, likeable MI5 agent inexplicably assigned to Slough House. •
Paul Higgins as Struan Loy (series 1), assigned after sending an inappropriate work email. •
Kadiff Kirwan as Marcus Longridge (series 2–4), • Hiba Bennani as Tara, Roddy's apparent girlfriend •
Harry Lloyd •
Kyle Soller •
Lucian Msamati •
MyAnna Buring •
Lenny Rush ==Episodes==