In 1843, she resigned her post at Mount Holyoke Seminary and went to Qajar Iran as a missionary among the Christian Assyrians (who were once called "
Nestorians" by Americans during the late 18th century, but is now an outdated term). Fisk had been recruited for the job by missionary
Justin Perkins to continue the work of Judith Grant, the wife of missionary
Asahel Grant. Fisk had labored in Iran for fifteen years, much of the time as teacher in a female seminary, she also served as a nurse and extended social support for some of her students. By her last year in Urmia 1858, she had some 40 students. It was upon her leaving the school was named "Fiske Seminary". == Late life and death ==