2022: Maiden Challenger title, ATP debut & first final, top 150 debut Ranked No. 301, Misolic won the
ATP Challenger singles title at the
2022 Zagreb Open. As a result he reached the top 250, climbing 76 positions up in the rankings to No. 225 on 16 May 2022. Next he defeated
Dusan Lajovic to reach the first ATP semifinal in his career. He reached his maiden ATP final defeating
Yannick Hanfmann in a final set tiebreak. As a result he moved close to 70 positions up the rankings in the top 150 to a new career-high of world No. 137 and became the Austrian player No. 1 on 1 August 2022. Ranked No. 181, he also qualified for the
2023 Stockholm Open and defeated eight seed
Dan Evans, before losing to eventual champion
Gael Monfils. He also qualified for his home tournament, the
2023 Erste Bank Open.
2024–2025: Major debut and third round, top 100 Ranked No. 241, he made his Grand Slam debut at the
2024 French Open after qualifying for the main draw, and defeated lucky loser
Otto Virtanen in five sets. As a result he moved more than 50 positions up, back into the top 200 in the rankings on 10 June 2024. Ranked No. 232 at the
2025 Țiriac Open, Misolic qualified for the main draw and defeated
Alexander Shevchenko and eight seed
Camilo Ugo Carabelli to reach his second ATP quarterfinal. As a result he moved close to 40 positions up in the rankings and returned to the top 200 on 7 April 2025. Misolic won his third ATP Challenger title at the
2025 Prague Open, defeating
Guy den Ouden in the final. Misolic qualified for the main draw of the
2025 French Open, defeating again second qualifying seed Alexander Shevchenko. Misolic defeated
Yunchaokete Bu, and 27th seed
Denis Shapovalov in five sets, to reach a major third round for the first time in his career. He lost to sixth seed
Novak Djokovic in the third round in straight sets. At the 30th edition of the
Enea Poznań Open, Misolic defeated
Dalibor Svrcina 6–2, 6–0 in the singles final in just 75 minutes, the third Austrian player in history to win the ATP Challenger 100 event. At the
2025 Nordea Open he reached his first ATP quarterfinal of the season, defeating defending champion
Nuno Borges after saving three match points. As a result he reached the top 100 in the singles rankings on 21 July 2025. == Performance timeline ==