In 2005, Dourif made her professional acting debut as Chez Ami Whore in the
HBO period drama series
Deadwood. The following year, she was cast as Alice in the television miniseries
Thief. The same year, Dourif made her debut film appearance in the drama
Little Chenier. In 2007, Dourif appeared in the off-Broadway play
Some Americans Abroad at
Second Stage Theater. Later, she was cast in the short film
The Lucky One. In 2008, Dourif portrayed Becky in the indie drama film
Garden Party and Lisa in
Frank the Rat. The same year, Dourif guest starred in the
NBC police procedural series
Law & Order: Special Victims Unit as Detective Nikki Breslin. In 2009, Dourif was cast in a small role in the film
The Messenger and had a guest role in the
HBO comedy series
Bored to Death. The following year, she starred in the indie film
Mafiosa and the television film
After the Fall. Dourif subsequently portrayed Penny in
Letters from the Big Man before having a recurring role as Casey in the HBO fantasy drama series
True Blood and a guest appearance in the
Lifetime police drama series
The Protector. In 2012, Dourif starred in the short film
This is Caroline and appeared in
Paul Thomas Anderson's psychological drama
The Master. In 2013, Dourif portrayed
Nica Pierce in the slasher film
Curse of Chucky, the sixth installment in the ''
Child's Play franchise in which her father, Brad Dourif, had starred as Chucky. The film was a critical success and became a cult hit. and in the 2021 television series continuation Chucky'', as well as playing the on-screen version of
Charles Lee Ray in flashbacks, the role her father played in the original
1988 film and returned to voice for the series. In 2014, she was cast in the indie films
Gutshot Straight,
Dangerous Words from the Fearless,
Precious Mettle, and
Fear Clinic. She also starred as Brie in the 2016 thriller film
Blood is Blood. From 2016 to 2017, Dourif played the "holistic assassin" Bart Curlish in the
BBC America science fiction comedy series ''
Dirk Gently's Holistic Detective Agency. The series ran for two seasons. Also in 2017, she portrayed the younger version of the character played by Rachel Griffiths, named Diane Jones, in the ABC docudrama miniseries When We Rise''. From 2018 to 2021, Dourif portrayed Jennifer Reddington, the long lost daughter of main character Raymond Reddington, in the
NBC drama thriller series
The Blacklist. She also had a recurring role in the
USA Network action horror series
The Purge as Good Leader Tavis, a zealous cult leader. In 2025, Dourif was cast as a series regular in the medical drama series
The Pitt as Dr. Cassie McKay. In April 2026, it was announced that Dourif would join the cast of the
Franz and Fiala film
Head Full of Ghosts. ==Filmography==